MONOVISC is a sterile, non-pyrogenic, sodium hyaluronate solution, lightly cross-linked with a proprietary chemical cross-linker.

  • Contains lightly cross-linked sodium hyaluronate (NaHA) dissolved in phosphate-buffered saline at physiological osmolality
  • Manufactured from ultra-pure, high molecular weight sodium hyaluronate produced by bacterial fermentation


MONOVISC Cross-Linked Sodium Hyaluronate Injection is a single, intra-articular injection of cross-linked sodium hyaluronate designed to treat the symptoms of osteoarthritis.


In the U.S., Monovisc is FDA - approved for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy or simple analgesics (e.g., acetaminophen).

Under the CE Mark, MONOVISC is indicated as a viscoelastic supplement or a replacement for synovial fluid in human joints.

  • Well suited for treatment of the symptoms of human joint dysfunctions such as osteoarthritis
  • The actions of MONOVISC are lubrication and mechanical support

Directions for use

The required amount of MONOVISC is injected through a sterile, disposable hypodermic needle of suitable gauge into the selected joint space.

Adverse reactions

Hyaluronic acid is a natural component of the tissues of the body. MONOVISC is thoroughly tested to determine that each batch conforms to the product quality attributes. Since sodium hyaluronate molecules are non-inflammatory, any phlogistic response is considered to be caused by the invasive procedure. Mild to moderate episodes of transient swelling and discomfort have occasionally been observed following intra-articular injection of sodium hyaluronate preparations. General risks associated with the procedure of injecting substances into joints may include infections and bleeding.

How supplied

MONOVISC is a sterile viscoelastic preparation supplied in a disposable glass syringe delivering 4.0 mL. Each syringe contains lightly cross-linked sodium hyaluronate dissolved in phosphate-buffered saline.


Please refer to the Instructions for Use for complete product information.